Accelerated aging syndromes, are they relevant to normal human aging?
نویسندگان
چکیده
منابع مشابه
Accelerated aging syndromes, are they relevant to normal human aging?
Hutchinson-Gilford Progeria (HGPS) and Werner syndromes are diseases that clinically resemble some aspects of accelerated aging. HGPS is caused by mutations in theLMNA gene resulting in post-translational processing defects that trigger Progeria in children. Werner syndrome, arising from mutations in the WRN helicase gene, causes premature aging in young adults. What are the molecular mechanism...
متن کاملThey Are Relevant to Human Disease
In a recent editorial in Stroke, 1 Wiebers, Adams, and Whisnant expressed their doubt about the relevance of drug studies in animal stroke models for development of therapy for the human disorder. They were particularly disturbed by the possibility that the use of animal models "may impede rather than advance scientific progress in the treatment of this disease." We want to debate this issue fr...
متن کاملThe rules of aging: are they universal? Is the yeast model relevant for gerontology?
The success of experimental biology was possible due to the use of model organisms. It is believed that the mechanisms of aging have a universal character and they are conserved in a wide range of organisms. The explanation of these universal mechanisms by tracing survival curves of model organisms clearly suggests that death of individuals is a direct consequence of aging. Furthermore, the use...
متن کاملAccelerated Heat Aging Study of Phenolic/Basalt Fiber Reinforced Composites
One of the greatest impediments to use polymer-matrix composites is their susceptibility to degradation when exposed to the elevated temperatures and the limited knowledge on the thermal and mechanical properties of these composites at such temperatures. The objective of this study is to evaluate the effects of accelerated heat aging on the tensile properties of the Woven Basalt/Phenolic (WBP) ...
متن کاملPTSD and Accelerated Aging
For hundreds of years, scientists have recognized that the human body is highly sensitive to the external environment. In the mid-1800s, Claude Bernard, who is credited with being among the first to develop and apply scientific methods of experimentation to the study of physiology, suggested that the external environment could alter the “milieu intérieur” (interior environment; Bernard, 1974), ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Aging
سال: 2011
ISSN: 1945-4589
DOI: 10.18632/aging.100383